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Inline Analysis

Inline Analysis

One of the advantages of flow chemistry is that is offers the opportunity of inline analysis. FutureChemistry has proven that their flow chemistry instruments can easily be connected to several analysis tools, allowing inline analysis.

Inline HPLC monitoring with the Wittig reaction

HPLCmonitoring

 

The Wittig reaction is used as a model reaction to monitor the outflow of a microreactor during predetermined intervals, using an inline HPLC method. A conventional Shimadzu HPLC system was coupled to the FlowStart B-200 microreactor system with a 6-port valve, which was automatically controlled by the HPLC software. This setup provided continuous, automated feedback on the conversion and stability of the process, without the need for sample-taking and subsequent work-up steps.

Future Chemistry Application Notes

• Automated Flow Process Development and Optimisation

 

 

Inline IR-Analysis: Controlled Vilsmeier–Haack Formylation of Electron-Rich Arenes

Inline-IRAnalysis

The Vilsmeier-Haack formylation of aromatic compounds is a well-established process in organic synthesis. Industrial-scale production, however, is often hampered by laborious procedures. In order to circumvent these issues, a flow chemistry approach was developed using Inline IR-Analysis.

Future Chemistry Application Notes

• Automated Flow Process Development and Optimisation
Vilsmeier-Haack literature

B.A.M.W. van den Broek, J.Leliveld, R., M.M.E Delville, P.J. Nieuwland, Kaspar Koch, and F. P. J. T. Rutjes Continuous flow production of thermally unstableintermediates in a microreactor with line IR-analysis:controlled Vilsmeier-Haack formylation of electron-rich arenes, 2012, OPRD,http://dx.doi.org/10.1021/op2003437

 

Inline GC monitoring (Fisher esterfication)

Fisher esterfication

 

The Fischer esterification was used as a model reaction in an automated optimisation, using an inline GC method.

Future Chemistry Application Notes

• Automated Flow Process Development and Optimisation

 

High-Resolution NMR Flow Probe

NMR_FlowChemistry

Researchers at the Radboud University Nijmegen, Twente University and FutureChemistry have developed a microfluidic high-resolution NMR flow probe. They have shown a model reaction being followed in real-time. The combination of the uncompromised (sub-Hz) resolution and a low sample volume can prove to be a valuable tool for flow chemistry.

More information of Flow Probe is found at: http://pubs.acs.org/doi/abs/10.1021/ja900389x

Set up used for this application:

FlowStart setup with 6-port valve connection in loop-mill mode

The application note describes the automated analysis of a continuous flow process using the FlowStart B-200 and a Shimadzu LC2010 HPLC system.

Login to the portal of FutureChemistry to download the application note.

Photochemistry

Exothermic reactions

Radiochemistry

Uniform Nanoparticles

Inline analysis

Use of gas in Flow