Photosensitized conjugate addition
Continuous flow photochemistry offers multiple advantages over batch-process photochemistry. Photochemical reactions are driven by the number of photons that are able to reach reactive molecules causing the activation and thus the desired reaction. In order to enhance reaction rate, the area of the reactor being reached by the light source can be increased. Using a microreactor, this can be achieved in a convenient way. We offer different solutions for different wavelengths. For wavelengths down to 365 nm, LED light sources can be used. For lower wavelengths, sufficiently powerful LED light sources are not available ; so for those applications conventional mercury lamp set ups are available.
A model reaction, the photosensitized conjugate addition of isopropanol to furanone, was successfully translated from batch to continuous flow in the FlowStart microreactor platform expanded with the Photochemistry module, showing the viability of continuous flow photochemistry.
This application note describes an application of the Photochemistry module.