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Scientific publications

Scientific publications

Our patented technology proved to be successful in organic synthetic reactions, such as oxidations, protecting group transformations and biocatalysed C-C bond formations.

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Youxin Fu, Hugo Helbert, Nadja A. Simeth, Stefano Crespi, Gerbren B. Spoelstra, Jan Maarten van Dijl, Marleen van Oosten, Luiza Reali Nazario, Dion van der Born, Gert Luurtsema, Wiktor Szymanski, Philip H. Elsinga, and Ben L. Feringa, Ultrafast Photoclick Reaction for Selective 18F-Positron Emission Tomography Tracer Synthesis in Flow, J. Am. Chem. Soc, 2021, 143, 27, 10041-10047,



J. J. F. van Gool, S. A. M. W. van den Broek, R. M. Ripken, P. J. Nieuwland, K. Koch, F. P. J. T. Rutjes, Highly Controlled Gas/Liquid Processes in a Continuous Lab-Scale Device, Chemical Engineering & Technology, 2013, 1042.

Lisette van Rens, Hans van Dijk, Jan Mulder, and Pieter Nieuwland, Using a Web Application To Conduct and Investigate Syntheses of Methyl Orange Remotely,


P. Watts, G. Pascali and P.A. Salvadori, Positron Emission Tomography Radiosynthesis in Microreactors, J. Flow Chem, 2012, 2, 37-42

Sebastiaan A. M. W.  van den Broek , René  Becker , Kaspar  Koch and Pieter J.  Nieuwland; Microreactortechnology: Real-Time Flow Measurements in Organic Synthesis Micromachines 2012, 3(2), 244-254;

B.A.M.W. van den Broek, R. Becker, F., M.M. E. Delville, P.J. Nieuwland, K. Koch and F.P.J.T. Rutjes; Prilezhaev Dihydroxylation of Olefins in a Continuous Flow Process, ChemSusChem, 2012,

B.A.M.W. van den Broek, J.Leliveld, R., M.M.E Delville, P.J. Nieuwland, Kaspar Koch, and F. P. J. T. Rutjes Continuous flow production of thermally unstableintermediates in a microreactor with line IR-analysis:controlled Vilsmeier-Haack formylation of electron-rich arenes, 2012, OPRD,

I. Dencic, V. Hessel, M.H.J.M. de Croon, J. Meuldijk, C.W.J. van der Doelen and K. Koch; Recent Changes in Patenting Behavior in Microprocess Technology and its Possible Use for Gas–Liquid Reactions and the Oxidation of Glucose, ChemSusChem, 2012,



P.J. Nieuwland, R. Segers, K. Koch, J.C.M. van Hest and F.P.J.T. Rutjes; Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale, Org. Process Res. Dev., 2011, 15 (4), pp 783–787,

R. Becker, K. Koch, P.J. Nieuwland and F.P.J.T. Rutjes; Flow chemistry today: practical approaches for optimisation and scale-up, Chimica Oggi, Chemistry Today. 2011, 29, 47-49



M.M.E Delville, P.J. Nieuwland, P. Janssen, K. Koch, J.C.M. van Hest and F.P.J.T. Rutjes; Continuous flow azide formation: Optimization and scale-up, Chemical Engineering Journal, 2010, 167, 556-559.

P.J. Nieuwland, K. Koch, N. van Harskamp, R. Wehrens, J.C.M. van Hest and F.P.J.T. Rutjes; Flash chemistry extensively optimized: high temperature Swern-Moffatt oxidation in an automated microreactor platform, Chemistry-an Asian Journal, 2010, 799-805.

P.J. Nieuwland, K. Koch, J.C.M. v. Hest and F.P.J.T. Rutjes; Flow markers in microreactors: a generally applicable  chromatographic method for monitoring flow rates during reactions, The Open Chemical Engineering Journal, 2010, Volume 4.

Catherine F. Carter, Heiko Lange, Steven V. Ley, Ian R. Baxendale, Brian Wittkamp, Jon G. Goode and Nigel L. Gaunt; ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing, Org. Process Res. Dev., 2010, 14 (2), 393-404.



K. Koch, B.J.A. van Weerdenburg, J.M.M. Verkade, P.J. Nieuwland, F.P.J.T. Rutjes and J.C.M. van Hest, Optimizing the Deprotection of the Amine Protecting p-Methoxyphenyl Group in an Automated Microreactor Platform, Org. Process Res. Dev., 2009, 13 (5), 1003-1006.

J. Bart, A.J. Kolkman, A.J. Oosthoek-de Vries, K. Koch, P.J. Nieuwland, J.W.G. Janssen, P.J.M. van Bentum, K.A.M. Ampt, F.P.J.T. Rutjes, S.S. Wijmenga, J.G.E. Gardeniers and A.P.M. Kentgens; A Microfluidic High-Resolution NMR Flow Probe, J. Am. Chem. Soc., Article, 2009, 5014.

K. Koch, S.S. van Berkel, M.M.E.B. van de Wal, P.J. Nieuwland, J.C.M. van Hest, F.P.J.T. Rutjes, Thrombin generation test in microfluidic systems, Journal of applied physics, 2009, 105, 102012.



K. Koch, F.P.J.T. Rutjes, J.C.M. van Hest, Microreactors in organic synthesis and catalysis,  Chapter 4.4 Bio-organic reactions, Wiley VCH, 2008.

K. Koch, R.J.F. van den berg, P.J. Nieuwland, R. Wijtmans, H. E. Schoemaker, J.C.M. van Hest, F.P.J.T. Rutjes, Enzymatic enantioselective C–C-bond formation in microreactors, Biotechnology and bioengineering, 2008, 99 (4), 1028-1033.

K. Koch, R.J. F. van den Berg, P.J. Nieuwland, R. Wijtmans, M.G. Wubbolts, H.E. Schoemaker, F.P.J.T. Rutjes and J.C.M. van Hest, Enzymatic synthesis of optically pure cyanohydrins in microchannels using a crude cell lysate, Chemical Engineering Journal, 2008, 135, S89-S92



P,J. Nieuwland, K. Koch, J.C.M. van Hest and Floris P.J.T. Rutjes, Ionic liquids in a microreactor: palladium catalysis, Proceedings of µTAS 2006 Conference, Tokyo, Japan, 2006, 870-872.

K. Koch, P. J. Nieuwland, H.E. Schoemaker, M.G. Wubbolts, F.P.J.T. Rutjes and J.C.M. van Hest, Screening multi-phase enzymatic reactions in a microreactor setup, Proceedings of µTAS 2006 Conference, Tokyo, Japan, 2006, 867-869.

K. Koch, R.J.F. van den Berg, P.J. Nieuwland, J.C.M. van hest, F.P.J.T. Rutjes, Multi-phase enzymatic synthesis in microchannels, Proceedings of IMRET 9, 2006, 196-197.



P.J. Nieuwland, K. Koch, M. Ueno, T. Kitamori, J.C.M. van Hest, F.P.J.T. Rutjes, Multi-Phase Two-Step Synthesis in Microreactors, Proceeding of µTAS 2005 Conference, Boston MA, USA 2005, 1434-1436.

K. Koch, R.J.F. van den Berg, P.J. Nieuwland , M. Ueno, T, Kitamori, F.P.J.T. Rutjes and J.C.M. Van Hest, Improved Multi-Phase Enzymatic Synthesis in a Microchannel, Proceeding of µTAS 2005 Conference,, Boston MA, USA 2005, 924-926.